After curing B liver for two years, the youth Li Li of Anhui signs vital footprint to stop forever at 19-year-old that year.Is Li Li to sign the family's agency lawyer, the Cheng Lin of lawyer from Lin law firm in Anhui sky thinks dead and use world that Li Li signs 500 strong business enterprise promise China system medicine(Peking) limited company treatment B liver medicine substitute to compare man settle(the company of telbivudine tablets uses "vegetable compare Fu") relevant, tell promise China to the Chang even area court of the people in Peking City in this year's beginning, "the bad reaction that intentionally conceals medicine" is its main articles.Death of young life with substitute to compare man settle whether have a direct relation?Have without cause an idea to conceal medicine bad reaction?Numerous questions cover with at the family of this sorrow.Nuo Hua denies that the medicine is causing death to give out the lawyer letter of promise China at the distance wood, Li Li signs the last time of life such Jian Lian:Li Li's signing(living in August, 1990) is diagnosed to get B liver in 2006 and start in the medicine department university of Anhui a first affiliated hospital to make a diagnosis and give treatment in December, 2006, on January 31, 2008 take substitute ratio man settle, the sufferer appears muscle ache in November, 2008, have no unwell symptoms like dint,etc, the Zun cures Zhu to stop using the medicine on December 8 and go into on December 2 rheumatism section, the condition continuously aggravates and turns highest sea Rui treatment in the gold hospital on December 25, the sufferer dies in on December 29 because of horizontal line muscle fuse the much dirty machine function that synthesize disease's cause crock up.According to the distance wood's parlance, Li Li signs to die in "take to substitute to compare man settle to of muscle damage", because of before now Li Li signed in a row take substitute ratio man settle 11 months.Although Li Li signed to take various medicine during the period of falling ill, distance wood said, sufferer at cured to use initial stage long time virtuous blessing Wei treatment,cheap sun glasses had no liver kidney at that time and other badly reaction, especially relevant CK(the creatine aroused Mao) and together the number of work Mao was more normal, had no muscle clinical symptom occurrence of painful etc.;And treatment in last phase take to pull rice man to settle also however 20 day.The death signed to Li Li with settle for the ratio man whether have direct relation, promise China gives a denial.Promise China at give the middle finger of replying of weekly paper reporter in ages, Li Li signs to die is that in order to using various anti- B liver virus medicine merger to cause, the severity badly responds to, not from substitute to compare man to certainly directly cause.Li Li signs at take for than the man periodical is to have a muscle disease, while the condition worsen and die this a series of affairs, all is stopping using to substitute to compare man to certainly change to use to pull rice man to take place after settling.Both parties' speech is as different as chalk and cheese, but all of basises are the mortality returns that matches the technique graduate school of the fatty city judicatory consultation science to.The consultation certificate that the reporter acquires shows:Li Li signs to fasten in taking anti- B liver virus medicine and substituting to compare man to settle to of muscle injuring foundation and change with anti- B liver virus medicine pull rice man settle, aggravated its muscle damage further, eventually to extensively horizontal line muscle fuse, and after hair the metabolism is sour poisoned, and heart, kidney, and lung...etc. many organs injure and arouse many organs to crock up to die and belong to serious medicine to badly respond a case.Nuo Hua means that before stopping substituting and comparing man and settling treatment, the sufferer appeared muscle ache and creatine to arouse Mao to heat up, there is no the diagnosis basis that the horizontal line muscle fuses a disease, the clinical doctor doubts to have a muscle disease and stopped using and substitute and compare man settle after changed and use and pull rice man settle.But the muscle disease is to substitute to compare man to settle manual in have already described and hinted badly to respond in detail, and the manual to doubt or confirm for muscle disease behind should carry on of the related processing have already told an user.Cheng Lin tells the weekly paper reporter in ages, the national drugs badly respond that the monitor center released on October 5, 2008[2008 zzs]No.337 drugs badly respond an information notification, the report suggests to is using the sufferer of "for compare to reply settle", periodically arrive the medical organization carries on a creatine to arouse Mao and lactic acid to take off hydrogen Mao, the blood elephant pH check, discover that the problem cures to rectify in time.Misery of BE, Li Li signs obviously didn't see this report, and his lord cure doctor to seem also didn't see, because he has never requested Li Li to sign periodical examination the CK wait number.According to the mortality return, medicine department university in Anhui the first affiliated hospital be thought the treatment behavior that signs to Li Li existence certain shortage, namely medical treatment mistake, and exist a certain cause and effect relation with of sufferer's death.Lateness of bad reaction elucidation because the judicial consultation can not prove death that Li Li signs with substitute to compare man to certainly have to directly relate to, the distance wood indicts the reason of promise China as"intentionally conceal the bad reaction of medicine".The distance wood hears the medical personnel of hospital speak of, the United States FDA announces in 2008 of the manual of telbivudine tablets, have already noted the bad reaction that the relevant horizontal line muscle fuses, but hasn't been suggesting in Chinese manual, can not make a modification to Chinese manual until Li Li signs January 4, 2009 after dying.Moreover, according to the distance wood's description, before October 5, 2008, gold China in Zhejiang has already appeared two death cases that substitute to compare man to certainly badly respond, there are also death cases like this in Wu lake in Anhui."We suppose promise China know to substitute to compare in October, 2008 man certificate of savings is badly responding, you by this time should adopt measure, if adopt measure at this time, notify each medical organization, the detail publicly and badly respond, I this party concerned can't die.Promise China held up too many time, and is have intention to hold up."Cheng Lin means.The report, modification that badly responds to promise China and Li Li signs the development of condition, the time node goes to a pass importance.However, the ages weekly paper reporter gets from promise China of the news is exactly clearly contrary.Nuo Hua means:"The United States FDA announces in 2008 of the manual of telbivudine tablets, have already noted relevant bad reaction that the horizontal line muscle fuses, isn't true.A version included the manual approval of bad reaction information that the horizontal line muscle fuses at the earliest stage in the United States is on January 23, 2009, the China concerning horizontal line muscle fused the renewal of information to acquire an approval on January 4, 2009."The ages weekly paper reporter checks the United States FDA official site and have never discovered 2008 the United States FDA the manual of telbivudine tablets of the announcement have already noted concerning the bad reaction circumstance that the horizontal line muscle fuses.The researcher of the Nuo Hua company medical science business department tells the weekly paper reporter in ages, substitute to compare man to certainly get batch to become available in the market on February 14, 2007 ex- clinical trial in, have never observed the horizontal line muscle fuses thus of bad reaction, basis Chinese relevant law laws and international usual practice, the drugs manual should be approved rear by the medicine Jian section to use, can not write in manual before getting to criticize.The above personage said that in October, 2008, promise China receives a world the first case confirms of the horizontal line muscle fuse case report, the sufferer's hasing been cured has already completely resumed.Immediately promise China handed in bad reaction to report at the same time to Chinese State Food and Drug Administration and FDA the United States and also put forward the application of manual renewal according to related rules in China and the request.Although declare at the same time, because of the United States FDA investigate procedure Be getting more complicated, consequently on January 4, 2009,The China concerning horizontal line muscle fuses the renewal of information to acquire an approval, while horizontal line muscle in the United States fuse of bad reaction information of the manual grant it is January 23, 2009, therefore the manual of Chinese version is early 20 days than the still taking of the English version.In the lately- modified Chinese manual on January 4, 2009, definitely added the contents that the relevant horizontal line muscle fuses-"muscle skeleton, knot Di organization and bone organization:The very rare horizontal line muscle fuses of report".Regret of BE, 4 days ago, Li Li signed to forever leave human life.The parlance of promise China got the verification of State Food and Drug Administration.The ages weekly paper reporter acquires from the State Food and Drug Administration news office of the document show:On November 17, 2008, the national drugs badly respond that the monitor center receives drugs in Zhejiang to badly respond 2 reports that is badly plain to respond a case than the related Fu of report in the monitor center.Be badly responded that first step evaluation in the monitor center thinks by national drugs, the use of these two cases and drugs is probably relevant.The document shows:Badly respond that the report has relation with monitor to stipulate and 《drugs manual and label manage rules (the bureau makes No.24)》 according to the our country drugs, the national bureau requests to produce a business enterprise further perfect manual contents, at[bad respond]increase in the item the horizontal line muscle fuses a related contents, the Nuo Hua company put forward in December, 2008 as to it's the manual carry on perfect, increment"horizontal line muscle fuse" of hint and related contents adds an application, and acquired an approval on January 4, 2009.On January 23, 2009, FDA increases a horizontal line muscle in the manual of the United States deliquescence to badly respond an information.Concerning substitute to compare man settle the manual"the rare horizontal line muscle fuses" of the approval of bad reaction information, China is early 20 days than the United States.Promise China(Novartis) means "new technique".Though there is in handling procedure no problem in promise China, but if promise China is receiving bad reaction to report and adopt more aggressive measure after confirming, at the time of reporting State Food and Drug Administration, at pay attention to new technique of also pay attention to a sufferer more at the same time, probably the final outcome will be different.Who check to surround for the drugs safety Li Li signs of dead,Mens RayBan Sunglasses still Yi cloud is layer after layer.Query of an is promise China to become available in the market in R.O.C quick speed.China is B liver outbreak to lead the tallest nation in the world, the conservative estimate virus takes about 130,000,000 people, the chronic B liver sufferer approaches 9000 myriad people.The promise China system medicine of substitute ratio man settle at Ge orchid vegetable the Shi Ke company He Pu D patent past expiration of date after gorgeous show up, and substitute ratio man settle in the United States get to criticize after only 4 months, passed a local examination and approval, quick its speed, controversial.The State Food and Drug Administration made to the weekly paper reporter in ages' querying response:The promise China system medicine limited company in Peking declares of substituting and comparing man settle the slice belong to domestic drugs, according to the rules of 《drugs register management way 》 , the national encouragement research creates to make a new medicine and quickly reviews to review to the new medicine execution that creates to make, examination and approval, the species belongs to creative drugs.Query of two is "vegetable than the Fu can not immediately stop a medicine once starting taking, otherwise occurrence explosion the liver crock up" that the industry puts forward, to this, the national State Food and Drug Administration didn't respond to.Nuo Hua means that large international and local clinical trials all proof, substitute to compare man to certainly have the case that much curative effect is good and carries out to stop a medicine, the chronic B liver cures guidebook to all put forward at home and abroad:Include to substitute to compare man to have already taken place relapse of illness risk after settling at inside of the pit Mao(is sour) of anti- B liver virus similar the thing stop the medicine, but don't mean that the sufferers that stop a medicine will take place to break out sex liver to crock up, more important want to stop a medicine under the doctor's instruction.Medicine department university in Chongqing is subsidiary second hospital open widely professor Zhi to mean while accepting the weekly paper reporter's interview in ages, the all pit Maos(is sour) similar thing all needs to cure over a long period of time, the sufferer who lead to early stop a medicine to all exist to relapse risk, but relapse's winning only separately a sufferer will take place liver to crock up;The cirrhosis sufferer's beard cures over a long period of time and leads to early stop liver to happen to medicine easily to crock up.According to know, the national drugs badly respond that the monitor center is organizing an expert currently the virussafe treatment medicine check Mao to the type of virus hepatitis similar thing if substitute to compare man to settle and pull rice man to certainly etc. species to carry on safety analysis and evaluation.Dying has been already gone, but concerning for settle than the man of various Yi cloud haven't spread to go, the case also still needs to continue, distance wood said to the reporter, will on July 1 after infringement responsibility method carry out again indict.After infringement responsibility method carries out again indict, can obtain more indemnification for victim, and the law eventually will make the verdict of a candor as well.
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